Ribosomal protein L7



Ribosomal protein L7 (RPL7) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is part of the L7/L12 complex. Two dimers of L7/L12 are present in the large subunit. The L7/L12 probably interacts with EF-Tu. L7 and L12 differ by one post-translational modification at the N-terminal of L7. In the archaea, the L7Ae acts as a subunit of RNase P.

3D Structures of Ribosomal protein L7
Update June 2011

RPL7
1rqu, 1rqv - EcRPL7 - Escherichia coli - NMR

1dd3, 1dd4 - TmRPL7/L12 - Thermotoga maritima

1rqs – EcRPL7/L12 - NMR

1rqt - EcRPL7/L12 N-terminal – NMR

1ctf - EcRPL7/L12 C-terminal

1ra4, 1xbi – MjRPL7Ae – Methasnocaldococcus jannaschii

1sds – MjRPL7Ae+box H/ACA RNA

2fc3 – RPL7Ae – Aeropyrum pernix

2czw – RPL7Ae – Pyrococcus horikoshii

1pxw - RPL7Ae – Pyrococcus abyssi

1rlg – RPL7Ae+RNA fragment – Archaeoglobus fulgidus

3pla - RPL7Ae + pre mRNA splicing protein + fibrillarin-like methyltransferase + RNA - Sulfolobus solfataricus

3o85 - RPL7Ae – Giardia lamblia

L7 in 50S subunit+RNA
2j01, 2j03, 1yl3, 3i8i, 1giy - TtRPL7 in 50S subunit+5S RRNA+23S RRNA

2gya, 2gyc - EcRPL7 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

2zjq, 2zjr - DrRPL7 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans

1kqs, 2qa4, 1qvg - HmRPL7 in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui

1jj2, 1ffk, 3cc2, 1s72 - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA

1vqm, 1vql, 1vq7, 1vq4, 1vq5, 1vqp - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+transition state analogue

3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA (mutant)

1yj9 - HmRPL7Ae in 50S subunit (mutant)+5S RRNA+23S RRNA

3cma, 3cme - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCA+CCA-Phe-CAP-BIO

1vq6, 1vqn - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+C-hpmn+CCA-Phe-CAP-BIO

1vqk, 1q86 - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCDA-Phe-CAP-BIO

1vqo - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCPMN

1qvf - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+deacylated tRNA minihelix

L7 in 50S subunit + antibiotics
3cxc – RPL7Ae in 50S subunit+5S RRNA+23S RRNA +oxazolidinone inhibitor – Halobacterium marismortui

1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 3qex, 3cpw, 3cc4, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+antibiotic

1m90 - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin

3cd6, 1yhq, 1yi2, 1yij, 1yjn, 1yjw - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic

1vq8, 1vq9 - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+CCDA-Phe-CAP-BIO+sparsomycin

L7 in 60S subunit
3jyw - RPL7 in 60S subunit – Thermomyces lanuginosus – Cryo-EM

3izr – RPL7 in 60S subunit – wheat – Cryo-EM

3o58, 3o5h – yRPL7 in 60S subunit+25S RRNA+5SRRNA+5.8RRNA

L7 in large + small ribosomal subunit
2zkr - RPL7 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM – dog

L7 in 50S subunit + various proteins
1w2b - HmRPL7Ae in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal

3lwo, 3lwp, 3lwq, 3lwr, 3lwv, 3hax, 3hay, 3hjw – PfRPL7Ae+pseudouridine synthase+ribosome biogenesis protein NOP10+H/ACA RNA+RNA fragment – Pyrococcus furiosus

2hvy - PfRPL7Ae+pseudouridine synthase+ribosome biogenesis protein NOP10+H/ACA RNA+small nucleolar RNP

3nmu - PfRPL7Ae + NOP5 related protein + RNA + fibrillarin-like methyltransferase

3id5 – SsRPL7Ae+pre RNA splicing protein+fibrillarin+half C/D RNA – Sulfolobus solfataricus

L7 in part of 50S subunit
2bcw – EcRPL7/L12+EcRPL11+EF-G

1zav, 1zaw, 1zax - TmRPL7/L12 N-terminal +RPL10